Case 33 of 40
Persistent confusion during alcohol withdrawal needs assessment for other causes
Example case for staff education
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Page 1
Panel 1: Day 1
He stopped drinking two days ago after becoming unwell.
Mina: He has barely eaten this week.
Panel 2: Day 1
Fever, cough and hypoxia accompany withdrawal symptoms.
Ward doctor Amira: We need to treat both withdrawal and the chest illness.
Panel 3: Day 1
A monitored withdrawal plan and thiamine treatment begin.
Nurse Tom: We will keep checking his breathing, alertness and symptoms.
Panel 4: Day 2
Pneumonia and metabolic problems are treated concurrently.
Ward doctor Amira: One diagnosis does not explain every finding.
Panel 5: Day 4
Tremor and sweating reduce; marked inattention remains.
Andrew: I cannot remember what you just asked.
Panel 6: Day 4
Persistent confusion prompts reassessment rather than automatic sedation.
Ward doctor Amira: Check what is still present and what may now be contributing.
Panel 7: Day 4
Ataxia and abnormal eye movements raise nutritional concerns.
Ward doctor Amira: Treat suspected Wernicke’s encephalopathy promptly.
Panel 8: Day 4
Treatment proceeds without waiting for a confirmatory test.
Nurse Tom: We will monitor the response and continue nutritional support.
Panel 9: Day 6
Some neurological signs improve before cognition.
Mina: He can sit better, but still forgets our conversation.
Page 2
Panel 10: Day 7
Ongoing infection, medicines and other causes are reviewed again.
Ward doctor Amira: We should not assume all remaining symptoms have one cause.
Panel 11: Day 9
Dietary support continues as intake improves.
Nurse Tom: Let us start with what you can manage comfortably.
Panel 12: Day 12
Mobility improves with help and repeated instructions.
Physiotherapist Lin: Pause before turning. I will stay alongside you.
Panel 13: Week 3
Memory and organisation still limit independence.
Andrew: I forget the next step unless someone reminds me.
Panel 14: Week 3
Early impairment does not establish a permanent prognosis.
Ward doctor Amira: We need to follow his recovery over time.
Panel 15: Week 4
Ongoing treatment is discussed when he can participate.
Alcohol liaison clinician Jo: What support would make it easier to continue treatment after discharge?
Panel 16: Week 5
The plan includes nutrition, medicines and cognitive follow-up.
Nurse Tom: The receiving team knows what help he still needs.
Panel 17: Week 8
Attention is clearer, but memory difficulties continue.
Andrew: I am better at talking than remembering what I need to do.
Panel 18: Week 8
The final outcome remains partial recovery.
Ward doctor Amira: We will reassess cognition and daily function while support continues.
Sources
- [S17] Jith, A., Mathew, K.A., Narayanan, D. and Jacob, S.M. (2021) ‘CASPR2 positive autoimmune encephalitis presenting as delirium in an alcohol dependent patient: a diagnostic dilemma’, Kerala Journal of Psychiatry, 34(1), pp. 54–56.
- [S22] Thukral, P., Sonavane, S., Shah, N., Kalra, G. and Desousa, A. (2013) ‘The conundrum of prolonged delirium’, The National Medical Journal of India, 26(3), pp. 150–151.
- [G05] National Institute for Health and Care Excellence. Alcohol-use disorders: diagnosis and management of physical complications. CG100.
- [G01] National Institute for Health and Care Excellence. Delirium: prevention, diagnosis and management in hospital and long-term care. CG103.


Commentary
Andrew’s history supports alcohol withdrawal, but he also has pneumonia and poor nutrition. Assess and treat these problems together. One explanation must not prevent treatment of another. Care includes a monitored withdrawal regimen and thiamine treatment suited to the clinical assessment [G05].
By day four, tremor and autonomic symptoms, including sweating, have reduced, but Andrew still has difficulty paying attention. Reassess him rather than automatically increasing sedating medicines. Consider sedation, infection, metabolic disturbance and nutritional disease. New poor coordination and abnormal eye movements raise concern about Wernicke’s encephalopathy. Treatment by injection starts without waiting for a confirmatory test. Improvement in those signs does not establish that all his problems with thinking have resolved.
The cited reports describe people whose symptoms continued to be attributed to withdrawal when their course required further investigation [S17, S22]. Andrew’s example does not include the uncommon diagnoses in those reports. Review the timing of symptoms, observed signs and treatment response, and assess additional possible causes when needed.
Andrew still has difficulties with memory and daily tasks during recovery. The team does not assign a permanent alcohol-related cognitive diagnosis at this early stage. Arrange support, nutritional care and alcohol-treatment follow-up alongside reassessment of thinking. Distinguish signs of withdrawal from signs of other illness, and check for treatment harms in a person who is already confused.