Case 34 of 40
Check for withdrawal when a regular medicine has been unintentionally stopped
Example case for staff education
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Page 1
Panel 1: Day 1
Pneumonia and new confusion make history-taking difficult.
Joan: I cannot remember all the names.
Panel 2: Day 1
The team seeks collateral information about regular medicines.
Nurse Tom: Please bring the medicines and any recent prescription list.
Panel 3: Day 2
Sleep loss, tremor and distress increase.
Joan: Something is terribly wrong. I cannot settle.
Panel 4: Day 2
The infection is improving, but the cognitive syndrome is worse.
Ward doctor Amira: We need to reassess causes, including recent medication changes.
Panel 5: Day 2
A long-standing lorazepam prescription is missing from the list.
Salim: She takes it every day, not just occasionally.
Panel 6: Day 2
Records establish regular use and an abrupt interruption.
Pharmacist Samir: We have confirmed when the last doses were taken.
Panel 7: Day 2
Withdrawal is considered alongside pneumonia and delirium.
Ward doctor Amira: Plan supervised treatment and monitor breathing and sedation.
Panel 8: Day 3
Tremor and distress begin to ease.
Nurse Tom: We will record the response, not assume every symptom will resolve.
Panel 9: Day 4
Attention remains impaired despite improvement in withdrawal symptoms.
Joan: What were we discussing?
Page 2
Panel 10: Day 5
Other causes and complications still require review.
Ward doctor Amira: The medication omission was important, but it was not the whole illness.
Panel 11: Day 6
Practical delirium care continues.
Nurse Tom: It is morning. We can start with a drink together.
Panel 12: Day 8
Clearer periods become longer.
Salim: You remembered more of our visit today.
Panel 13: Day 10
She still needs prompts for daily activities.
Occupational therapist Ruth: We will practise before deciding how much help you need.
Panel 14: Week 3
The omission and its consequences are explained.
Ward doctor Amira: We also need to review whether this remains the right long-term treatment.
Panel 15: Week 3
Any later reduction will be agreed and gradual.
Joan: I want to understand the plan before changing it.
Panel 16: Week 4
The dose, timing and review arrangements are explicit.
Nurse Tom: Contact the prescriber if there is a problem obtaining or taking it.
Panel 17: Week 5
Cognitive recovery continues with temporary support.
Salim: I will help until we know this is reliable.
Panel 18: Week 6
The acute episode has improved; medication review continues.
Joan: I am ready to talk about the next steps.
Sources
- [T02] MacLullich AMJ. Persistent delirium. CHG Singapore teaching presentation, 2025. Teaching slides.
- [S25] Sanders, B.J. and Ali, Z.A. (2021) ‘Oral Baclofen Withdrawal Resulting in Hyperactive Delirium: A Case Report’, Cureus, 13(5), e14979.
- [G06] National Institute for Health and Care Excellence. Medicines associated with dependence or withdrawal symptoms: safe prescribing and withdrawal management for adults. NG215.
- [G01] National Institute for Health and Care Excellence. Delirium: prevention, diagnosis and management in hospital and long-term care. CG103.


Commentary
Joan’s admission list omits a medicine she has taken regularly for years. She is unable to give a complete history, so information from others and pharmacy records are particularly useful. Confirm which doses she actually took and when. A medicine may cause problems while it is being taken, and abrupt withdrawal may cause different problems.
Joan has pneumonia, disrupted sleep, tremor and new severe anxiety with delirium. Once regular lorazepam use and its omission are confirmed, withdrawal becomes a plausible additional cause. Plan treatment under appropriate clinical supervision, taking account of her respiratory illness and the risk of sedation. This case gives no standard restart dose and does not suggest that every omitted medicine should be resumed unchanged [G06].
The cited teaching presentation and baclofen report describe the value of checking medicines actually taken, although they concern different drugs and circumstances [T02, S25]. Joan’s sequence and response were created for this teaching example. Her tremor and distress improve before her attention. Correcting the omission does not remove the need to assess and care for continuing delirium.
After acute recovery, review the long-term prescription with Joan. Plan any agreed reduction gradually rather than stopping abruptly. Keep that later review separate from urgent treatment of withdrawal. Identify how the omission occurred and how the missing information was found. Include the dose, timing and review arrangements in transfer information to prevent another interruption.