Case 35 of 40
Treat delirium and distress according to the person’s wishes in advanced cancer
Example case for staff education
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Read the case transcript
Page 1
Panel 1: Before admission
Naomi has advanced cancer but can discuss her care.
Naomi: Being able to talk with you matters most to me.
Panel 2: Day 1
A new cognitive change develops with reduced intake.
Joel: She could follow our conversation yesterday.
Panel 3: Day 1
Hypercalcaemia, dehydration and constipation complicate the acute illness.
Ward doctor Amira: Review medicines too, while considering her goals and the burden of treatment.
Panel 4: Day 1
Treatment is planned around her condition and known wishes.
Ward doctor Amira: We can treat these problems while keeping her comfort central.
Panel 5: Day 2
Physical comfort and fear are addressed together.
Nurse Tom: Tell me what feels uncomfortable. I will go slowly.
Panel 6: Day 3
Some symptoms improve after treatment.
Naomi: I am glad you are here.
Panel 7: Day 3
A meaningful conversation does not mean delirium has resolved.
Joel: We had a few minutes together, then she became confused again.
Panel 8: Day 4
The team reassesses benefit and treatment burden.
Ward doctor Amira: We will continue what helps and reconsider what is causing difficulty.
Panel 9: Day 5
Reduced movement does not establish relief of distress.
Nurse Tom: Are you feeling frightened now?
Page 2
Panel 10: Day 6
The wider illness is progressing despite proportionate treatment.
Ward doctor Amira: We need to review what further treatment could realistically achieve.
Panel 11: Day 6
Her earlier wishes guide discussion alongside current findings.
Joel: She wanted comfort and time with people she knows.
Panel 12: Day 7
Symptoms are treated and the response observed closely.
Nurse Tom: We are checking comfort, not simply whether she is quiet.
Panel 13: Day 7
Family contact continues without demanding a response.
Joel: You do not need to answer. I am here.
Panel 14: Day 8
Care adapts as she communicates less.
Nurse Tom: We will keep looking for signs of pain or distress.
Panel 15: Day 8
The team explains that cognitive recovery has not occurred.
Ward doctor Amira: We will continue caring for her comfort and supporting you.
Panel 16: Day 9
She dies with family present and ongoing comfort care.
Joel: Thank you for helping us stay together.
Panel 17: Afterwards
The family can discuss what happened and ask questions.
Ward doctor Amira: What would you like us to go through with you?
Panel 18: Afterwards
The outcome is death, with care continuing throughout the illness.
Joel: Those few clear moments mattered.
Sources
- [S09] Dunphy, L., Akin-Komolafe, T. and Etheridge, Z. (2021) ‘Mixed dementia and hyperactive delirium: a diagnostic challenge’, BMJ Case Reports, 14(5), e238542.
- [S10] Lou, K., Minhas, S. and Nayar, S. (2022) ‘Dermatomyositis Related Paraneoplastic Encephalitis Presenting as Terminal Delirium in the Palliative Care Unit – A Case Report’, Journal of Palliative Care, 37(3), pp. 270–272.
- [S14] Silva, T.O., Angeli-Faez, B., Paixão, L.C.F., Maraldi, E. de O. and Moreira-Almeida, A. (2026) ‘End-of-life dreams and visions in a patient with delirium: A Brazilian case report and narrative review’, Palliative and Supportive Care, 24, e4, pp. 1–10.
- [S15] Breitbart, W. and Alici, Y. (2008) ‘Agitation and delirium at the end of life: “We couldn’t manage him”’, JAMA, 300(24), pp. 2898–2910, E1.
- [T01] MacLullich AMJ. Conceptualising distress in delirium. Usher teaching presentation, May 2026. Teaching slides.


Commentary
Naomi has advanced cancer, but her sudden change still needs assessment. Consider high calcium levels, dehydration, constipation and medicine effects in relation to her care goals and the burdens of treatment. Offer proportionate treatment for possible causes while addressing fear and discomfort. Agitation or a cancer diagnosis alone is not a reason to label delirium terminal.
Naomi becomes comfortable enough for a short conversation with Joel, but her attention remains inconsistent. The conversation is valuable to them without establishing that she has recovered from delirium. Palliative care reports describe goals such as contact with family or relief of specific symptoms [S10, S14, S15]. They do not establish that every person will respond to treatment in the same way.
When Naomi deteriorates later, staff reassess her progressive illness, previous wishes and course so far. They decide to focus on comfort after this review, rather than because delirium has lasted a set number of days. Monitor medicines for severe symptoms for both intended benefits and burdens. Reduced activity alone does not establish that distress has been relieved [T01].
Naomi dies with Joel present. She does not fully recover from delirium. Care, communication and attention to suffering continue throughout her illness. Keep reviewing which treatments are proportionate and how to recognise distress as she communicates less. Explain uncertainty to relatives without promising recovery or assuming that rapid deterioration is inevitable.